Services

Epigenetics Consortium provides an array of services in a variety of medicinal, biological and chemical disciplines.

• Fee per sample or collaboration arrangements

• Contact Natalia Tretyakova with questions

Epigenetic Marks

• • Quantitative analysis of 5-methyl-dC and 5-hydroxymethyl-dC in DNA using isotope dilution HPLC-ESI-MS/MS – Natalia Tretyakova

  • Identification and quantification of histone marks – Yue Chen

  • Affinity proteomics -- Natalia Tretyakova

Biological and Screening Services (ITDD)

• • Biochemical and cell-based assay development and validation

  • Low-, medium-, and high-throughput assays including those at biosafety level 3 (BSL-3).

  • Low throughput assay development and implantation

  • NCI cancer cell panel cytotoxicity screening

  • Simplex & Multiplex intracellular signaling molecule measurement

  • Compound profiling services

  • hERG channel profiling

  • ITC profiling

  • High content image analysis profiling of cellular toxicity reporters

  • Screening library containing 300,000 compounds

  • Focused libraries of pharmacologically active compounds for assay & target validation

Medicinal, Organic, and Process Chemistry (ITDD)

• • Structure-Activity Relationship (SAR)

  • Lead and Probe Optimization

  • Parallel synthesis and chemical library production

  • Total and multi-step synthesis of natural products

  • Rational, protein-structure based and computational drug design

  • Synthesis of lead molecules, drug candidates, and advanced intermediates on a diverse scale (mg to kg)

  • Chemical process development, scale-up, and optimization

  • Active Pharmaceutical Ingredients (API) synthesis under cGMP conditions (mg to kg) to support pre-clinical and Phases I-II clinical trials

  • API stability testing

  • Protein purification