Past Seminars
2023
April 20, 2023
Martin Matzuk, M.D., PhD
Department Chair
Department of Pathology and Immunology
Baylor College of Medicine
“DNA-Encoded Chemistry Technology and Genetics for Interrogation of Reproduction”
March 16, 2023
Kristin Koutmou, PhD
Assistant Professor
Department of Chemistry
University of Michigan
“Incorporation and consequences of mRNA modifications”
February 16, 2023
Anang Shelat, PhD
Associate Member and Director
Lead Discovery Informatics and Compound Management, St. Jude Children's Research Hospital
“Bromodomain Selective Therapy for Pediatric Cancers”
January 19, 2023
Jeffrey Gross, PhD
Professor & Department Chair
Molecular Biosciences, College of Natural Sciences, University of Texas
“Epigenetic Regulation of Retina Development & Regeneration”
2022
December 15, 2022
Michiel Vermeulen, PhD
Professor
Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Netherlands
“Deciphering Gene Expression Regulation in Health and Disease Using Integrative Omics Approaches”
November 17, 2022
Babal K. Jha, PhD
Associate Professor
Cleveland Clinic Lerner College of Medicine of CWRU
“TET Dioxygenase Deficiency Creates a Targetable Vulnerability in Malignant Cells”
October 27, 2022
Aleksey Matveyenko, PhD
Professor of Physiology
Mayo Clinic College of Medicine
“Circadian Etiology of Type 2 Diabetes”
April 21, 2022
**Virtual**
Dr. Neil Kelleher, PhD
Professor of Chemistry
Northwestern University
“Decoding the Proteoform Composition of Endogenous Nucleosomes with Nuc-MS”
March 17, 2022
**Virtual**
Dr. Fraser Hof, PhD
Professor of Chemistry
University of Victoria
“Chemical Tools for Studying and Disrupting Protein Methylation Pathways”
February 17, 2022
**Virtual**
Dr. Danica Galonić Fujimori, PhD
Professor of Cellular and Molecular Pharmacology, University of California-San Francisco
“Function and Inhibition of Readers of Chromatin Methylation”
January 20, 2022
**Virtual**
Dr. Edwina Yeung, PhD
Senior Investigator, National Institutes of Health
“Parental Exposures on Offspring DNA Methylation”
2021
November 18, 2021
Dr. Qing Lin, PhD
Professor of Chemistry, University of Buffalo
“Bioorthogonal Chemistry Approach to Study Class B GPCR Dynamics”
April 15, 2021
Ralph Kleiner, PhD
Assistant Professor of Chemistry, Princeton University
"Chemical Approaches to Illuminate the RNA Epitranscriptome"
March 18, 2021
Vadim Backman, PhD
Walter Dill Scott Professor of Biomedical Engineering, Northwestern University
"Understanding the ‘Operating System’ of the Genome: The Structure and Function of Chromatin Packing"
February 18, 2021 - NOTE: 2:00pm CST
Daniel Harki, PhD
Associate Professor and Director of Graduate Studies of Medicinal Chemistry, University of Minnesota
"Targeting Transcription Factor - DNA Interfaces with Natural Product-Inspired Electrophiles"
January 21, 2021
Ian Maze, PhD
Associate Professor, Departments of Neuroscience and Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
"Protein Monoaminylation in Brain: Novel Mechanisms of Neural Development, Plasticity and Disease"
2020
December 17, 2020
Huarui Cui
Graduate Student, Pomerantz Lab, University of Minnesota
"Selective N‐terminal BRD4 Bromodomain Inhibitors by Targeting Non‐conserved Residues and Structured Water Displacement"
Andrew Rajczewski
Graduate Student, Tretyakova Lab, University of Minnesota
"Quantitative Proteomics of Epigenetic Proteins in Inflamed Systems"
THESIS DEFENSE - December 11, 2020
Jenna Fernandez
PhD Candidate, Tretyakova Lab, University of Minnesota
"Epigenetic Mechanisms in Lung Cancer Development"
Join Zoom Meeting: https://umn-private.zoom.us/j/91272317160?pwd=TzVzMVo5UGhjS0doTnE0SUFsL2...
Meeting ID: 912 7231 7160
Passcode: #pfcr5
Yael David, Sloan Kettering Institute, Memorial Sloak Kettering Cancer Center
“Uncovering Cancer-Associated Epigenetic Events Using Novel Chemical Tools”
October 2020
https://www.mskcc.org/research/ski/labs/yael-david
Mrinal Patnaik, Mayo Clinic
"Epigenetic Alterations and Therapeutic Targets in Chronic Myelomonocytic Leukemia"
September 2020
https://www.mayo.edu/research/faculty/patnaik-mrinal-s-m-b-b-s/bio-00093620
Steven Johnsen, Mayo Clinic
"In Situ Detection of Enhancer RNAs in a Novel Mechanism-based Epigenetic Stratification of Pancreatic Cancer"
May 2020
https://www.mayo.edu/research/faculty/johnsen-steven-a-ph-d/bio-20463596
David Largaespada, University of Minnesota
"Exploiting Synthetic Vulnerabilities from Loss of an Epigenetic Writer in Malignant Peripheral Nerve Sheath Tumors"
March 2020
https://www.cancer.umn.edu/bio/cancer-center-leadership/david-largaespada
Brian Smith, Medical College of Wisconsin
"Discovering and Exploiting Selectivity in Bromodomain Recognition of Lysine Acylation"
February 2020
https://www.mcw.edu/departments/biochemistry/people/brian-smith-phd
Douglas Thomas, The University of Illinois at Chicago
"The Third Pillar of Nitric Oxide Signaling"
January 2020
2019
Natalia Tretyakova, University of Minnesota (Mayo Clinic Epigenetics Seminar)
"Imbalance of DNA Methylation and Demethylation in Inflammation, Cancer, and Alzheimer's disease"
December 2019
https://www.pharmacy.umn.edu/bio/pharmacy-faculty-a-z/natalia-tretyakova
Stuart Conway, University of Oxford
"Chemical Tools to Target Hypoxia and Epigenetic Targets"
October 2019
http://research.chem.ox.ac.uk/stuart-conway.aspx
Scott Dehm, University of Minnesota
"Role of Androgen Receptor and Androgen Receptor Variants in Prostate Cancer"
September 2019
https://med.umn.edu/bio/lab-med-and-pathology-faculty/scott-dehm
Yue Chen, University of Minnesota (Mayo Clinic Epigenomics Seminar)
"Characterization of Oxygen-dependent Posttranslational Modifications with Quantitative Proteomics"
August 2019
https://cbs.umn.edu/contacts/yue-chen
Kabirul Islam, University of Pittsburgh
"An Orthogonal Chromatin Landscape with Engineered Protein and Small Molecules"
April 2019
https://www.chem.pitt.edu/person/kabirul-islam
Micah Gearhart, University of Minnesota
"Transcriptional Regulation by the Polycomb Repressive Complex 1.1 in Development and Disease"
March 2019
https://cbs.umn.edu/contacts/micah-gearhart-phd
Wei Chen, University of Pittsburgh
"DNA Methylation in Atopy and Atopic Asthma"
February 2019
https://publichealth.pitt.edu/home/directory/wei-chen
Keith Robertson, Mayo Clinic
"Universtanding and Targeting the Epigenome in Liver Cancer"
January 2019
https://www.mayo.edu/research/faculty/robertson-keith-d-ph-d/bio-20035097
2018
Joseph Landry, Virginia Commonwealth University
"Enhancement of Breast Tumor Cell Immunogenicity as a Strategy for Chemosensitization"
November 2018
https://medschool.vcu.edu/expertise/detail.html?ID=1990
Shujun Liu, Hormel Institute
"A Dynamic N6-methyladenosine Methylome Regulates Intrinsic and Acquired Drug Resistance"
October 2018
https://www.hi.umn.edu/portfolio-items/shujun-liu/
Jorden Johnson & Anand Divakaran, Graduate Students
"3D-Enriched Fragment Screening and Selective N-Terminal BET Bromodomain Inhibition in the Pomerantz Lab"
September 2018
2017
Winnie Tang, Johns Hopkins University
“Tet1-mediated DNA Hydroxymethylation and Airway Hyperresponsiveness”
April 2017
https://www.jhsph.edu/faculty/directory/profile/2430/winnie-wan-yee-tang
Timothy Hallstrom, University of Minnesota
“Epigenetics at the Proliferation/Differentiation Switch in Retinal Progenitor Cells”
March 2017
https://www.cancer.umn.edu/bio/cancer-center-leadership/timothy-hallstrom
James Kiefer, Genentech Inc.
"How We Learned to Stop Chelating and Love Histone Demethylases"
February 2017
https://www.gene.com/scientists/our-scientists/jim-kiefer
Brian Van Ness, University of Minnesota
"Targeting the Epigenome in Multiple Myeloma”
January 2017
2016
Christine Wendt, M.D., University of Minnesota
"A Trans-omic Approach to Uncover Pre-Malignant Pathways in COPD-associated Lung Cancer"
November 2016
https://med.umn.edu/bio/meet-our-graduate-faculty/christine-wendt
Alasdair Reid, Illumina, Inc.
"Illuminating the Methylome"
October 2016
Rahul Kohli, University of Pennsylvania
"Cytosine Modifying Enzymes and the Dynamic Genome"
September 2016
https://www.med.upenn.edu/apps/faculty/index.php/g275/p6341532
Max Costa, NYU School of Medicine
"Metals Epigenetics and Cancer"
May 2016
https://med.nyu.edu/faculty/max-costa
Peter Jones Presentation, Van Andel Research Institute
April 2016
Dr. Laura Hawk, Postdoctoral Associate, UMN Department of Chemistry
"Chemical Biology Approaches for Inhibiting Protein Recognition of Acetylated Histones"
February 2016
2015
Dr. Shujun Liu, Associate Professor, Cancer Epigenetics & Experimental Therapeutics, The Hormel Institute
"AML1/ETO-HIF1a-DNMT3a Axis Defines Unique Epigenetic Patterns in AML Cells"
November 2015
Dr. Kenneth Beckman, Director, University of Minnesota Genomics Center
"Genomic Methods for Measuring DNA Methylation"
October 22, 2015
Li-Na Wei, Department of Pharmacology, Distinguished McKnight Professor, U of MN
"RIP140 in epigenetic control of ESC "Stemness" and Neural Progenitor Cell homeostasis"
September 3, 2015
Zhiguo Zhang, Department of Biochemistry/Cancer Epigenetics Lab, Mayo Clinic
"Epigenetic Inheritance & Impacts on Histone Mutations on Cancer Epigenomes"
July 31, 2015
MinnCResT Epigentics Symposium July 20, 2016
Agenda
Introduction
Mark C. Herzberg, DDS, PhD
Director, Minnesota Craniofacial Research Training
Program
KEYNOTE ADDRESS
“Chromatin Structure, Epigenetic Mechanisms, and Long Range Interactions in the Nucleus”
Gary Felsenfeld, PhD
NIH Distinguished Investigator
National Institute of Diabetes and Digestive and Kidney Diseases, NIH
“DNA Demethylation and Inflammation-Mediated Epigenetic Changes”
Natalia Y. Tretyakova, PhD
Professor of Medicinal Chemistry
University of Minnesota Cancer Center
"Dioxygenases: Unexpected Epigenetic Targets of Oncometabolites and Antibiotics?”
Jim Maher, PhD
Professor, Department of Biochemistry and Molecular Biology
Dean Mayo Graduate School, Mayo Clinic, Rochester, MN
“Epigenomics as a roadmap to understanding disease-associated variation in noncoding DNA”
Matthew Slattery, PhD
Department of Biomedical Sciences
University of Minnesota Medical School, Duluth
MinnCResT Fellows’ Recognition—all are encouraged to attend
Opening Remarks and Recognition of MinnCResT Fellows
Mark Herzberg, DDS, PhD
MinnCResT Fellows’ presentations—Three-minute thesis challenge
Kyle Biesecker, PhD-candidate
Jeff Hall, PhD
Fahad Kidwai, DDS, PhD
“Hidden in Plain Sight: Role of long non-coding RNA PVT1 in human cancer
Anindya Bagchi, PhD
Dept. of Genetics, Cell Biology & Development, University of Minnesota
“Lysine acylations - a complex paradigm for the metabolic regulation of gene expression”
Yue Chen, PhD
Dept. of Biochemistry, Molecular Biology & Biophysics, University of Minnesota
Epigenetics Symposium April 2016
Cheryl Arrowsmith
University of Toronto & Toronto’s Structural Genomics Consortium
"Probing the Epigenome with Chemical Biology"
Theresa Alenghat
Cincinnati Children’s Hospital
"Epigenomic Regulation of the Host-microbe Relationship"
Steve Belinsky
Lovelace Biomedical & Environmental Research Institute
"DNA Repair capacity and the epigenome in lung cancer pre-malignancy"
Natalia Tretyakova
UMN Medicinal Chemistry
"DNA methylation and demethylation and epigenetic inhibitor development"
Ben Garcia
School of Medicine, University of Pennsylvania
"Quantitative proteomics for understanding modified proteins and proteomes"
Jeff Simon
University of Minnesota
"Polycomb group (PcG) transcriptional repressors"
Yi Zhang
Harvard Medical School and Howard Hughes Medical Institute
"Identifying and overcoming an epigenetic reprogramming barrier by somatic cell nuclear transfer"
Will Pomerantz
UMN Chemistry
"Choosing the right halogen: Fluorinated bromodomains for chemical probe discovery"
Epigenetics: Development, Psychopathology, Resilience, and Prevention Intervention
May 8, 2015
Yue Chen, Department of Biochemistry, Molecular Biology &
Biophysics, U of M
"MS-based Discovery & Quantification of Histone Epigenetic Markers"
Gunda Georg, Department of Medicinal Chemistry, U of M
"Discovery of BRDT Inhibitors for Male Contraception"
Will Pomerantz, Department of Chemistry, U of M
"19F as a Small Molecule Ligand Discovery Platform for Epigenetic Proteins"
Natalia Tretyakova, Department of Medicinal Chemistry, U of M
"Epigenetic Changes in Lung Cancer"
May 2015 – First Meeting
Epigenetics: Main Players, Role in Disease, and Therapeutic Targets
Yue Chen
Department of Biochemistry, Molecular Biology & Biophysics
University of Minnesota
"MS-based Discovery & Quantification of Histone Epigenetic Markers"
Gunda Georg
Department of Medicinal Chemistry
University of Minnesota
"Discovery of BRDT Inhibitors for Male Contraception"
Will Pomerantz
Department of Chemistry
University of Minnesota
"19F as a Small Molecule Ligand Discovery Platform for Epigenetic Proteins"
Natalia Tretyakova
Department of Medicinal Chemistry
University of Minnesota
"Epigenetic Changes in Lung Cancer"