Past Seminars


April 20, 2023

Martin Matzuk, M.D., PhD

Department Chair 

Department of Pathology and Immunology

Baylor College of Medicine

“DNA-Encoded Chemistry Technology and Genetics for Interrogation of Reproduction”

March 16, 2023

Kristin Koutmou, PhD

Assistant Professor

Department of Chemistry

University of Michigan

Incorporation and consequences of mRNA modifications

February 16, 2023

Anang Shelat, PhD

Associate Member and Director

Lead Discovery Informatics and Compound Management, St. Jude Children's Research Hospital

Bromodomain Selective Therapy for Pediatric Cancers

January 19, 2023

Jeffrey Gross, PhD

Professor & Department Chair

Molecular Biosciences, College of Natural Sciences, University of Texas

“Epigenetic Regulation of Retina Development & Regeneration”


December 15, 2022

Michiel Vermeulen, PhD


Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Netherlands

“Deciphering Gene Expression Regulation in Health and Disease Using Integrative Omics Approaches”

November 17, 2022

Babal K. Jha, PhD

Associate Professor

Cleveland Clinic Lerner College of Medicine of CWRU

“TET Dioxygenase Deficiency Creates a Targetable Vulnerability in Malignant Cells”

October 27, 2022

Aleksey Matveyenko, PhD

Professor of Physiology

Mayo Clinic College of Medicine

“Circadian Etiology of Type 2 Diabetes”

April 21, 2022


Dr. Neil Kelleher, PhD

Professor of Chemistry

Northwestern University

“Decoding the Proteoform Composition of Endogenous Nucleosomes with Nuc-MS”

March 17, 2022


Dr. Fraser Hof, PhD

Professor of Chemistry

University of Victoria

“Chemical Tools for Studying and Disrupting Protein Methylation Pathways”

February 17, 2022


Dr. Danica Galonić Fujimori, PhD

Professor of Cellular and Molecular Pharmacology, University of California-San Francisco

“Function and Inhibition of Readers of Chromatin Methylation”

January 20, 2022


Dr. Edwina Yeung, PhD

Senior Investigator, National Institutes of Health

“Parental Exposures on Offspring DNA Methylation”


November 18, 2021

Dr. Qing Lin, PhD

Professor of Chemistry, University of Buffalo

“Bioorthogonal Chemistry Approach to Study Class B GPCR Dynamics”

April 15, 2021

Ralph Kleiner, PhD

Assistant Professor of Chemistry, Princeton University

"Chemical Approaches to Illuminate the RNA Epitranscriptome"

March 18, 2021

Vadim Backman, PhD

Walter Dill Scott Professor of Biomedical Engineering, Northwestern University

"Understanding the ‘Operating System’ of the Genome: The Structure and Function of Chromatin Packing"

February 18, 2021 - NOTE: 2:00pm CST

Daniel Harki, PhD

Associate Professor and Director of Graduate Studies of Medicinal Chemistry, University of Minnesota

"Targeting Transcription Factor - DNA Interfaces with Natural Product-Inspired Electrophiles"

January 21, 2021

Ian Maze, PhD

Associate Professor, Departments of Neuroscience and Pharmacological Sciences, Icahn School of Medicine at Mount Sinai

"Protein Monoaminylation in Brain: Novel Mechanisms of Neural Development, Plasticity and Disease"


December 17, 2020

Huarui Cui

Graduate Student, Pomerantz Lab, University of Minnesota

"Selective N‐terminal BRD4 Bromodomain Inhibitors by Targeting Non‐conserved Residues and Structured Water Displacement"

Andrew Rajczewski

Graduate Student, Tretyakova Lab, University of Minnesota

"Quantitative Proteomics of Epigenetic Proteins in Inflamed Systems"

THESIS DEFENSE - December 11, 2020

Jenna Fernandez

PhD Candidate, Tretyakova Lab, University of Minnesota

"Epigenetic Mechanisms in Lung Cancer Development"

Join Zoom Meeting:

Meeting ID: 912 7231 7160

Passcode: #pfcr5

Download Flier Here

Yael David, Sloan Kettering Institute, Memorial Sloak Kettering Cancer Center

“Uncovering Cancer-Associated Epigenetic Events Using Novel Chemical Tools”

October 2020

Mrinal Patnaik, Mayo Clinic

"Epigenetic Alterations and Therapeutic Targets in Chronic Myelomonocytic Leukemia"

September 2020

Steven Johnsen, Mayo Clinic

"In Situ Detection of Enhancer RNAs in a Novel Mechanism-based Epigenetic Stratification of Pancreatic Cancer"

May 2020

David Largaespada, University of Minnesota

"Exploiting Synthetic Vulnerabilities from Loss of an Epigenetic Writer in Malignant Peripheral Nerve Sheath Tumors"

March 2020

Brian Smith, Medical College of Wisconsin

"Discovering and Exploiting Selectivity in Bromodomain Recognition of Lysine Acylation"

February 2020

Douglas Thomas, The University of Illinois at Chicago

"The Third Pillar of Nitric Oxide Signaling"

January 2020


Natalia Tretyakova, University of Minnesota (Mayo Clinic Epigenetics Seminar)

"Imbalance of DNA Methylation and Demethylation in Inflammation, Cancer, and Alzheimer's disease"

December 2019

Stuart Conway, University of Oxford

"Chemical Tools to Target Hypoxia and Epigenetic Targets"

October 2019

Scott Dehm, University of Minnesota

"Role of Androgen Receptor and Androgen Receptor Variants in Prostate Cancer"

September 2019

Yue Chen, University of Minnesota (Mayo Clinic Epigenomics Seminar)

"Characterization of Oxygen-dependent Posttranslational Modifications with Quantitative Proteomics"

August 2019

Kabirul Islam, University of Pittsburgh

"An Orthogonal Chromatin Landscape with Engineered Protein and Small Molecules"

April 2019

Micah Gearhart, University of Minnesota

"Transcriptional Regulation by the Polycomb Repressive Complex 1.1 in Development and Disease"

March 2019

Wei Chen, University of Pittsburgh

"DNA Methylation in Atopy and Atopic Asthma"

February 2019

Keith Robertson, Mayo Clinic

"Universtanding and Targeting the Epigenome in Liver Cancer"

January 2019


Joseph Landry, Virginia Commonwealth University

"Enhancement of Breast Tumor Cell Immunogenicity as a Strategy for Chemosensitization"

November 2018

Shujun Liu, Hormel Institute

"A Dynamic N6-methyladenosine Methylome Regulates Intrinsic and Acquired Drug Resistance"

October 2018

Jorden Johnson & Anand Divakaran, Graduate Students

"3D-Enriched Fragment Screening and Selective N-Terminal BET Bromodomain Inhibition in the Pomerantz Lab"

September 2018


Winnie Tang, Johns Hopkins University

“Tet1-mediated DNA Hydroxymethylation and Airway Hyperresponsiveness”

April 2017

Timothy Hallstrom, University of Minnesota

“Epigenetics at the Proliferation/Differentiation Switch in Retinal Progenitor Cells”

March 2017

James Kiefer, Genentech Inc.

"How We Learned to Stop Chelating and Love Histone Demethylases"

February 2017

Brian Van Ness, University of Minnesota

"Targeting the Epigenome in Multiple Myeloma”

January 2017


Christine Wendt, M.D., University of Minnesota

"A Trans-omic Approach to Uncover Pre-Malignant Pathways in COPD-associated Lung Cancer"

November 2016

Alasdair Reid, Illumina, Inc.

"Illuminating the Methylome"

October 2016

Rahul Kohli, University of Pennsylvania

"Cytosine Modifying Enzymes and the Dynamic Genome"

September 2016

Max Costa, NYU School of Medicine

"Metals Epigenetics and Cancer"

May 2016

Peter Jones Presentation, Van Andel Research Institute

April 2016

Dr. Laura Hawk, Postdoctoral Associate, UMN Department of Chemistry

"Chemical Biology Approaches for Inhibiting Protein Recognition of Acetylated Histones"

February 2016


Dr. Shujun Liu, Associate Professor, Cancer Epigenetics & Experimental Therapeutics, The Hormel Institute

"AML1/ETO-HIF1a-DNMT3a Axis Defines Unique Epigenetic Patterns in AML Cells"

November 2015

Dr. Kenneth Beckman, Director, University of Minnesota Genomics Center

"Genomic Methods for Measuring DNA Methylation"

October 22, 2015

Li-Na Wei, Department of Pharmacology, Distinguished McKnight Professor, U of MN

"RIP140 in epigenetic control of ESC "Stemness" and Neural Progenitor Cell homeostasis"

September 3, 2015

Zhiguo Zhang, Department of Biochemistry/Cancer Epigenetics Lab, Mayo Clinic

"Epigenetic Inheritance & Impacts on Histone Mutations on Cancer Epigenomes"

July 31, 2015

MinnCResT Epigentics Symposium July 20, 2016



Mark C. Herzberg, DDS, PhD

Director, Minnesota Craniofacial Research Training



“Chromatin Structure, Epigenetic Mechanisms, and Long Range Interactions in the Nucleus”

Gary Felsenfeld, PhD

NIH Distinguished Investigator

National Institute of Diabetes and Digestive and Kidney Diseases, NIH

“DNA Demethylation and Inflammation-Mediated Epigenetic Changes”

Natalia Y. Tretyakova, PhD

Professor of Medicinal Chemistry

University of Minnesota Cancer Center

"Dioxygenases: Unexpected Epigenetic Targets of Oncometabolites and Antibiotics?”

Jim Maher, PhD

Professor, Department of Biochemistry and Molecular Biology

Dean Mayo Graduate School, Mayo Clinic, Rochester, MN

“Epigenomics as a roadmap to understanding disease-associated variation in noncoding DNA”

Matthew Slattery, PhD

Department of Biomedical Sciences

University of Minnesota Medical School, Duluth

MinnCResT Fellows’ Recognition—all are encouraged to attend

Opening Remarks and Recognition of MinnCResT Fellows

Mark Herzberg, DDS, PhD

MinnCResT Fellows’ presentations—Three-minute thesis challenge

Kyle Biesecker, PhD-candidate

Jeff Hall, PhD

Fahad Kidwai, DDS, PhD

“Hidden in Plain Sight: Role of long non-coding RNA PVT1 in human cancer

Anindya Bagchi, PhD

Dept. of Genetics, Cell Biology & Development, University of Minnesota

 “Lysine acylations - a complex paradigm for the metabolic regulation of gene expression”

Yue Chen, PhD

Dept. of Biochemistry, Molecular Biology & Biophysics, University of Minnesota

Epigenetics Symposium April 2016

Download schedule pdf

Cheryl Arrowsmith

University of Toronto & Toronto’s Structural Genomics Consortium

"Probing the Epigenome with Chemical Biology"

Theresa Alenghat

Cincinnati Children’s Hospital

"Epigenomic Regulation of the Host-microbe Relationship"

Steve Belinsky

Lovelace Biomedical & Environmental Research Institute

"DNA Repair capacity and the epigenome in lung cancer pre-malignancy"

Natalia Tretyakova

UMN Medicinal Chemistry

"DNA methylation and demethylation and epigenetic inhibitor development"

Ben Garcia

School of Medicine, University of Pennsylvania

"Quantitative proteomics for understanding modified proteins and proteomes"

Jeff Simon

University of Minnesota

"Polycomb group (PcG) transcriptional repressors"

Yi Zhang

Harvard Medical School and Howard Hughes Medical Institute

"Identifying and overcoming an epigenetic reprogramming barrier by somatic cell nuclear transfer"

Will Pomerantz

UMN Chemistry

"Choosing the right halogen: Fluorinated bromodomains for chemical probe discovery" 

Epigenetics: Development, Psychopathology, Resilience, and Prevention Intervention

May 8, 2015

Yue Chen, Department of Biochemistry, Molecular Biology & 

Biophysics, U of M

"MS-based Discovery & Quantification of Histone Epigenetic Markers"

Gunda Georg, Department of Medicinal Chemistry, U of M

"Discovery of BRDT Inhibitors for Male Contraception"

Will Pomerantz, Department of Chemistry, U of M

"19F as a Small Molecule Ligand Discovery Platform for Epigenetic Proteins"

Natalia Tretyakova, Department of Medicinal Chemistry, U of M

"Epigenetic Changes in Lung Cancer"

May 2015 – First Meeting

Epigenetics: Main Players, Role in Disease, and Therapeutic Targets

Yue Chen

Department of Biochemistry, Molecular Biology & Biophysics

University of Minnesota

"MS-based Discovery & Quantification of Histone Epigenetic Markers"

Gunda Georg

Department of Medicinal Chemistry

University of Minnesota

"Discovery of BRDT Inhibitors for Male Contraception"

Will Pomerantz

Department of Chemistry

University of Minnesota

"19F as a Small Molecule Ligand Discovery Platform for Epigenetic Proteins"

Natalia Tretyakova

Department of Medicinal Chemistry

University of Minnesota

"Epigenetic Changes in Lung Cancer"